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  Indian J Med Microbiol
 

Figure 2: Proposed processes of inhibition of synaptic transmission in the neuromuscular synapse during the acute period of COVID infection. Notes: (1) Increase in the amplitude and frequency of the action potential in response to the appearance of IL-1, IL-2, IL-6, TNF-α, γ; activation of calcium channels; (2) Stimulation of ACh exocytosis; (3) Increase in the amount of ACh in the synapse; (4) Decreased amplitude and increased time of action of ACh on the postsynaptic membrane; (5) Modification of ACh, Na+ receptors, phospholipids under the action of peroxynitrite; activation of autoimmune inflammation; (6) Oxidation of membrane cholesterol; (7) Violation of actin-mysional conjugation and relaxation. TNF-α: Tumor necrosis factor-alpha, IL-1: Interleukin-1, ACh: Acetylcholine.

Figure 2: Proposed processes of inhibition of synaptic transmission in the neuromuscular synapse during the acute period of COVID infection. Notes: (1) Increase in the amplitude and frequency of the action potential in response to the appearance of IL-1, IL-2, IL-6, TNF-α, γ; activation of calcium channels; (2) Stimulation of ACh exocytosis; (3) Increase in the amount of ACh in the synapse; (4) Decreased amplitude and increased time of action of ACh on the postsynaptic membrane; (5) Modification of ACh, Na<sup>+</sup> receptors, phospholipids under the action of peroxynitrite; activation of autoimmune inflammation; (6) Oxidation of membrane cholesterol; (7) Violation of actin-mysional conjugation and relaxation. TNF-α: Tumor necrosis factor-alpha, IL-1: Interleukin-1, ACh: Acetylcholine.