Figure 4: Silence of GATA4 alleviated hippocampal apoptosis in Aβ1–42 fibril-infused rats. (a) Injection with sh-GATA4 virus reduced the number of TUNEL-positive cells in Aβ-infused rats. (b) Injection with sh-GATA4 virus increased protein expression of Bcl-2 and decreased Bax in the hippocampus of Aβ-infused rats. *** versus sham, P < 0.001. ### versus Aβ + sh-NC, P < 0.001. GATA4: GATA4-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.