Figure 2: Silence of GATA4 alleviated morphological changes in Aβ1–42 fibril-infused rats. (a) Injection with sh-GATA4 virus ameliorated the pathological changes in hippocampus of Aβ-infused rats through increase of neurons. N = 6. (b) Injection with sh-GATA4 virus reduced amyloid plaques deposition in hippocampus of Aβ-infused rats. (c) Knockdown of GATA4 reduced anti-amyloid beta (6E10) in hippocampal tissues of Aβ-infused rats. N = 6. *** versus sham, P < 0.001. ### versus Aβ + sh-NC, P < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.