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  Indian J Med Microbiol
 

Figure 2: Silence of GATA4 alleviated morphological changes in Aβ1–42 fibril-infused rats. (a) Injection with sh-GATA4 virus ameliorated the pathological changes in hippocampus of Aβ-infused rats through increase of neurons. N = 6. (b) Injection with sh-GATA4 virus reduced amyloid plaques deposition in hippocampus of Aβ-infused rats. (c) Knockdown of GATA4 reduced anti-amyloid beta (6E10) in hippocampal tissues of Aβ-infused rats. N = 6. *** versus sham, P < 0.001. ### versus Aβ + sh-NC, P < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.

Figure 2: Silence of GATA4 alleviated morphological changes in Aβ<sub>1–42</sub> fibril-infused rats. (a) Injection with sh-GATA4 virus ameliorated the pathological changes in hippocampus of Aβ-infused rats through increase of neurons. <i>N</i> = 6. (b) Injection with sh-GATA4 virus reduced amyloid plaques deposition in hippocampus of Aβ-infused rats. (c) Knockdown of GATA4 reduced anti-amyloid beta (6E10) in hippocampal tissues of Aβ-infused rats. <i>N</i> = 6. *** versus sham, <i>P</i> < 0.001. <sup>###</sup> versus Aβ + sh-NC, <i>P</i> < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.