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  Indian J Med Microbiol
 

Figure 1: Silence of GATA4 alleviated learning and memory impairments in Aβ1–42 fibril-infused rats. (a) GATA4 was elevated in hippocampus of Aβ-infused rats, and injection with sh-GATA4 virus reduced the expression of GATA4. (b) Injection with sh-GATA4 virus decreased escape latency of Aβ-infused rats. (c) Representative images of the swim paths of rats on day 6 in different groups. Black dot was the location of the platform. (d) Injection with sh-GATA4 virus increased number of platform crossings of Aβ-infused rats on day 6 of spatial probe test. (e) Injection with sh-GATA4 virus increased time in target quadrant of Aβ-infused rats on day 6 of spatial probe test. *** versus sham, P < 0.001. ##, ### versus Aβ + sh-NC, P < 0.01, P < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.

Figure 1: Silence of GATA4 alleviated learning and memory impairments in Aβ<sub>1–42</sub> fibril-infused rats. (a) GATA4 was elevated in hippocampus of Aβ-infused rats, and injection with sh-GATA4 virus reduced the expression of GATA4. (b) Injection with sh-GATA4 virus decreased escape latency of Aβ-infused rats. (c) Representative images of the swim paths of rats on day 6 in different groups. Black dot was the location of the platform. (d) Injection with sh-GATA4 virus increased number of platform crossings of Aβ-infused rats on day 6 of spatial probe test. (e) Injection with sh-GATA4 virus increased time in target quadrant of Aβ-infused rats on day 6 of spatial probe test. *** versus sham, <i>P</i> < 0.001. <sup>##</sup>, <sup>###</sup> versus Aβ + sh-NC, <i>P</i> < 0.01, <i>P</i> < 0.001. GATA4: GATA-binding protein 4, sh-GATA4: shRNA targeting GATA4, sh-NC: negative control.