Figure 3: Acidity-suppressed Mn²⁺ influx triggered by cinacalcet. bEND.3 cells were bathed in 1 mM Ca²⁺-containing solution of different pH, treated with 1 mM Mn²⁺, followed by the addition of DMSO or 10 mM cinacalcet. At pH 7.4, significant differences (P < 0.05) between the control and cinacalcet groups began after 200 s. Results are mean ± SEM; each group had 29-108 cells obtained from three to nine separate experiments. SEM: Standard error of the mean, DMSO: dimethyl sulfoxide.