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  Indian J Med Microbiol
 

Figure 4: Effects of Gap26 on MVD and BBB permeability after BYHWD treatment at 7 days post MCAO (mean ± SEM, n = 6). (a) Immunofluorescent staining of CD31-positive MVD in hippocampal CA1, CA3, and dentate gyrus. Blue was staining of DAPI (cell nuclei), and green was staining of CD31. (b-d) Quantitative analysis of MVD in CA1, CA3, and dentate gyrus, respectively. (e) Schematic diagram indicated the brain area chosen for immunofluorescence. (f) Representative pictures of Evans blue staining. (g) Quantitative analysis of Evans blue leakage in each group. *P < 0.05 versus Sham, #P < 0.05 versus MCAO, and P < 0.05 versus BYHWD. Scale bar: 20 μm. BYHWD: Buyang Huanwu decoction; MCAO: Middle cerebral artery occlusion; MVD: Microvascular density; BBB: Blood-brain barrier.

Figure 4: Effects of Gap26 on MVD and BBB permeability after BYHWD treatment at 7 days post MCAO (mean ± SEM, <i>n</i> = 6). (a) Immunofluorescent staining of CD31-positive MVD in hippocampal CA1, CA3, and dentate gyrus. Blue was staining of DAPI (cell nuclei), and green was staining of CD31. (b-d) Quantitative analysis of MVD in CA1, CA3, and dentate gyrus, respectively. (e) Schematic diagram indicated the brain area chosen for immunofluorescence. (f) Representative pictures of Evans blue staining. (g) Quantitative analysis of Evans blue leakage in each group. *<i>P</i> < 0.05 versus Sham, <sup>#</sup><i>P</i> < 0.05 versus MCAO, and <i>P</i> < 0.05 versus BYHWD. Scale bar: 20 μm. BYHWD: Buyang Huanwu decoction; MCAO: Middle cerebral artery occlusion; MVD: Microvascular density; BBB: Blood-brain barrier.