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Figure 8: Effect of AMPKα inhibitor and mTOR inhibitor on expression of autophagy-related proteins, ER stress-related proteins and p-eNOS (Ser1177) in rat mesenteric arteries. (a) Representative blots. (b) Quantification of protein expression levels of Beclin-1. (c) Quantification of protein expression levels of LC3-II/I. (d) Quantification of protein expression levels of GRP78. (e) Quantification of protein expression levels of CHOP. (f) Quantification of protein expression levels of p-eNOS (Ser1177). Values were mean ± SEM, n = 4 (Beclin-1, CHOP, eNOS) and 5 (LC3-II/I, GRP78) in each group. *P < 0.05, **P < 0.01 versus MS; #P < 0.05, ##P < 0.01 versus MS + CIHH. CIHH: Chronic intermittent hypobaric hypoxia; AMPK: Adenosine mono-phosphate-activated protein kinase; mTOR: Mammalian target of rapamycin; ER stress: Endoplasmic reticulum stress; eNOS: Endothelial nitric oxide synthase; MS: Metabolic syndrome; CON: Control. |
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