Figure 1: Effects of adropin and spexin hormones on renal function parameters in adenine induced CKF. 24-h urine samples were collected and its volume was recorded. Urine total protein, urine creatinine, urine protein loss, serum creatinine and BUN were measured by an automatic biochemistry analyzer. Creatinine clearance and protein/creatinine ratio were calculated. Data are expressed as mean ± S. D. One-way ANOVA and Mann-Whitney U test were used to evaluate the differences between the groups. Protein/creatinine ratio is compared by Pearson correlation test. ***P < 0.001, **P < 0.01 and *P < 0.05 versus vehicle group. ++P < 0.01 and +P < 0.05 versus CKF group (n = 5).