Figure 3: Expression of p38 MAPK, interleukin-18 receptor, and cell size after the H9c2 cells were treated with the SB203580 (SB) and drugs. (a and b) Interleukin-18 significantly increased H9c2 cell size which was attenuated by SB pretreatment. (c) Pretreatment with SB significantly decreased the interleukin-18-induced increases in interleukin-18 receptor protein expression (n = 6). (d) Adenine (Ade) but not gold nanoparticles (Au) significantly augment phosphor-p38 MAPK and p38 MAPK ratio inhibition by SB pretreatment. (n = 4) ^##P < 0.01, compared with control ^#P < 0.01, compared with interleukin-18 **P < 0.05, compared with control * P < 0.05, compared with SB+interleukin-18