Chinese Journal of Physiology

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 64  |  Issue : 4  |  Page : 177--185

Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma


Chih-Hsiang Tsou1, Lin-Sen Pon2, Jun-Zhi Liang3, Yun-Hsiang Chan4, Kuan-Jung Chen4, Feng-Shiang Cheng5, Tsair Kao6, Sai-Wei Yang7 
1 Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taiwan
2 Department of Electric Engineering, Chinese Culture University, Taipei, Taiwan
3 Department of Physics, Fu-Jen Catholic University, New Taipei City, Taiwan
4 Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan
5 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
6 Medical Division, ACME Portable Machines, Inc., New Taipei City, Taiwan
7 Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan

Correspondence Address:
Dr. Chih-Hsiang Tsou
No.10, Sec. 4, Ren-Ai Rd., Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei
Taiwan

Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.


How to cite this article:
Tsou CH, Pon LS, Liang JZ, Chan YH, Chen KJ, Cheng FS, Kao T, Yang SW. Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma.Chin J Physiol 2021;64:177-185


How to cite this URL:
Tsou CH, Pon LS, Liang JZ, Chan YH, Chen KJ, Cheng FS, Kao T, Yang SW. Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma. Chin J Physiol [serial online] 2021 [cited 2021 Oct 20 ];64:177-185
Available from: https://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=177;epage=185;aulast=Tsou;type=0