| REVIEW ARTICLE |
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| Year : 2023 | Volume
: 66
| Issue : 1 | Page : 1-13 |
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Cholinergic deficiency in the cholinergic system as a pathogenetic link in the formation of various syndromes in COVID-19
Sergey Petrovich Lysenkov1, Dmitriy Vitalevich Muzhenya1, Aminat Ramazanovna Tuguz2, Tamara Ur'evna Urakova1, Dmitriy Sergeevich Shumilov2, Ibragim Askarbievich Thakushinov1, Rustem Askarbievich Thakushinov1, Elena Anatolevna Tatarkova2, Diana Muratovna Urakova1
1 FSBEI HE “Maikop State Technological University”, Medical Institute, Maikop, Republic of Adygeya, Russia
2 FSBEI HE “Adyghe State University”, Immunogenetic Laboratory of the Research Institute of Complex Problems, Maikop, Republic of Adygeya, Russia
Correspondence Address:
Asst. Prof. Dmitriy Vitalevich Muzhenya
Department of Pathomorphology and Clinical Pathophysiology, Medical Institute, FSBEI HE “Maikop State Technological University”, Maikop, Republic of Adygeya
Russia
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/cjop.CJOP-D-22-00072
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According to recent data, several mechanisms of viral invasion of the central nervous system (CNS) have been proposed, one of which is both direct penetration of the virus through afferent nerve fibers and damage to the endothelium of cerebral vessels. It has been proven that the SARS-CoV-2 virus affects pathologically not only the human cardiorespiratory system but is also associated with a wide range of neurological diseases, cerebrovascular accidents, and neuromuscular pathologies. However, the observed post-COVID symptom complex in patients, manifested in the form of headache, “fog in the head,” high temperature, muscle weakness, lowering blood pressure, does it make us think about the pathophysiological mechanisms that contribute to the development of this clinical picture? One possible explanation is a disruption in the signaling of the acetylcholine system (AChS) in the body. Viral invasions, and in particular COVID-19, can negatively affect the work of the AChS, disrupting its coordination activities. Therefore, the main goal of this literature review is to analyze the information and substantiate the possible mechanisms for the occurrence of post-COVID syndrome in people who have had COVID-19 from the standpoint of AChS dysfunctions.
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