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Year : 2022  |  Volume : 65  |  Issue : 5  |  Page : 258-265

ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D

1 Department of Hepatological Surgery, Changshu Second People's Hospital, Suzhou, Jiangsu Province, China
2 Department of Hepatological Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, China

Correspondence Address:
Dr. Jihu Zheng
Department of Hepatological Surgery, Changshu Second People's Hospital, No. 18 Taishan Road, Changshu 215500, Jiangsu Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0304-4920.359795

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Hepatocellular carcinoma is a common malignant tumor with high recurrence rate. Long non-coding RNA (lncRNA) ZNF561 antisense RNA 1 (ZNF561-AS1) functions as an oncogenic lncRNA to promote the tumorigenesis of colorectal cancer. The role of ZNF561-AS1 in hepatocellular carcinoma remains unknown. ZNF561-AS1 was elevated in hepatocellular carcinoma tissues and cells. Silence of ZNF561-AS1 reduced cell viability and inhibited the proliferation of hepatocellular carcinoma. The angiogenesis of hepatocellular carcinoma was also suppressed by loss of ZNF561-AS1 with a decrease of angiopoietin 2, fibroblast growth factor 1, and vascular endothelial growth factor. ZNF561-AS1 bind to miR-302a-3p, and decreased expression of miR-302a-3p in hepatocellular carcinoma. Moreover, miR-302a-3p reduced platelet-derived growth factor-D (PDGFD) in hepatocellular carcinoma, and inhibition of miR-302a-3p attenuated ZNF561-AS1 silence-induced decrease of PDGFD. In conclusion, silence of ZNF561-AS1 might inhibit cell proliferation and angiogenesis of hepatocellular carcinoma through downregulation of miR-302a-3p-mediated PDGFD.

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