• Users Online: 424
  • Print this page
  • Email this page
Year : 2022  |  Volume : 65  |  Issue : 4  |  Page : 159-170

Dose-dependent effect of retrieval-extinction on preventing reinstatement of cocaine-associated memory in mice

1 Department of Psychology; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
2 Department of Psychology, National Cheng Kung University, Tainan, Taiwan

Correspondence Address:
Dr. Sherry Shu-Jung Hu
Cannabinoid Signaling Laboratory, Department of Psychology, National Cheng Kung University, 1 University Road, Tainan 70101
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0304-4920.354804

Rights and Permissions

As a noninvasive behavioral intervention, the retrieval-extinction (R-E) procedure has drawn much research attention for its capacity to target the reconsolidation of maladaptive memories. However, later research findings suggest that the cause and consequence of R-E may be more complicated than previously suggested. For example, the R-E procedure could increase an animal's motivation for drug-seeking under certain circumstances, and the reversed extinction-retrieval (E-R) procedure could also suppress the drug memory. Two possible mechanisms underlying the R-E procedure have been proposed: the reconsolidation-update and extinction-facilitation hypotheses. To elucidate the paradoxical prior findings and examine these two hypotheses, we systematically examined the efficacy of the extinction (E), R-E, and E-R procedures in mice's low-dose versus high-dose cocaine-induced conditioned place preference (CPP) memory. We showed that the dose of cocaine is a crucial determinant of the efficacy of the three behavioral interventions. The E procedure exerted a long-lasting suppression of the low-dose cocaine CPP memory, while the R-E procedure induced more memory defects than the E and E-R procedures in its long-term suppression of the high-dose cocaine CPP memory. It warrants further investigation of whether the R-E procedure's underlying neurochemical and molecular mechanisms differ from the E and E-R procedures.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded91    
    Comments [Add]    

Recommend this journal