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ORIGINAL ARTICLE
Year : 2021  |  Volume : 64  |  Issue : 4  |  Page : 177-185

Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma


1 Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taiwan
2 Department of Electric Engineering, Chinese Culture University, Taipei, Taiwan
3 Department of Physics, Fu-Jen Catholic University, New Taipei City, Taiwan
4 Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan
5 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
6 Medical Division, ACME Portable Machines, Inc., New Taipei City, Taiwan
7 Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan

Correspondence Address:
Dr. Chih-Hsiang Tsou
No.10, Sec. 4, Ren-Ai Rd., Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/cjp.cjp_19_21

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Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.


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