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Year : 2020  |  Volume : 63  |  Issue : 6  |  Page : 245-249

Interplay of COVID-19 and physiological dysfunctions

1 Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan
2 Department of Physiology and Biophysics, National Defense Medical Center; Department of Medical Research, Tri-Service General Hospital, Taipei, Taiwan

Correspondence Address:
Prof. Po-Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, No. 161, Section 6, Min-Chuan East Road, Taipei 114
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CJP.CJP_91_20

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The outbreak of the global coronavirus disease 2019 (COVID-19) pandemic continues to impact the socioeconomic fabric and the general well-being of numerous populations and communities around the world. As cases continue to rise exponentially, gaining a better understanding of the pathophysiology and the associated clinical implications of SARS-CoV-2, the causative agent of COVID-19, becomes increasingly necessary. In this article, we delineate the role of COVID-19 in physiological and immunological dysfunction. Specifically, we highlight the various possible mechanisms and effects of SARS-CoV-2 infections on major organ systems as well as their contribution toward multiorgan system failure. By analyzing studies and statistics regarding various comorbidities in COVID-19 patients, we make inferences on the linkage between COVID-19, immune injury, multiorgan system damage, and disease progression.

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