• Users Online: 326
  • Print this page
  • Email this page
Year : 2019  |  Volume : 62  |  Issue : 5  |  Page : 203-209

Magnesium sulfate attenuates lipopolysaccharides-induced acute lung injury in mice

Department of Pathogenic Microbiology, Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, Yinchuan; Department of Microbiology and Molecular Biology, College of Life Science, Ningxia University, Yinchuan, Ningxia, China

Correspondence Address:
Prof. Guangcun Deng
College of Life Science, Ningxia University, 539 W. Helanshan Road, Yinchuan, Ningxia 750021
Prof. Yujiong Wang
College of Life Science, Ningxia University, 539 W. Helanshan Road, Yinchuan, Ningxia 750021
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CJP.CJP_48_19

Rights and Permissions

Acute lung injury (ALI) is a common and severe respiratory disease with high morbidity and mortality. Although some progress has been made in the past years, the pathogenesis of ALI is still poorly understood and the therapeutic outcome has still not been significantly improved. It is well-recognized that magnesium sulfate (MgSO4) possesses potent anti-inflammation capacity. The present study was designed to investigate the protective effects of MgSO4 in lipopolysaccharides (LPSs)-induced ALI taken into account that excessive inflammatory response plays critical role in the development of ALI. In this study, Kunming mice were intravenously injected with LPS through tail vein to establish the ALI model and in parallel, A549 cells were used to establish cell model. The lung wet-to-dry weight ratio, malondialdehyde (MDA) levels in lung tissue, lung permeability index, hematoxylin and eosin staining, cytokines in the serum and bronchoalveolar lavage fluid (BALF), neutrophil counts in BALF, LPS-induced A549 cell apoptosis as well as apoptosis-inducing factor (AIF), and Poly(ADP-ribose) polymerase-1 (PARP-1) expression in both mice and A549 cells were detected. Our results demonstrated that MgSO4 significantly attenuated the LPS-induced ALI, oxidative stress (decreased MDA levels), and lung inflammatory response. Moreover, MgSO4 exerted protective effects by mitigating LPS-induced A549 cell apoptosis. Furthermore, MgSO4 decreased the AIF and PARP-1 expression both in vivo and in vitro. Our results, taken together, demonstrated that MgSO4 is a potential therapeutic agent for ALI taken into consideration that MgSO4 is commonly used in clinical settings.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded594    
    Comments [Add]    
    Cited by others 10    

Recommend this journal